When we have a new newton telescope we shroud avoid touch the collimation of the secondary mirror as we may get into troubles.
You no more need large sensors and heavy equipment to do good general photos. The recent development of image sensors put silicon chip capabilities to it's limit by
Knowing what you are looking for is more then half way to achieving it. Breakthrough Listen is a SETI kind of project that listen for artificial signals from 1700 nearby stars up to 160 light years.
Some shots from Sofia. A very bright sky place. Zenith sky brightness info (2015): SQM 19.13 mag./arc sec2 Brightness 2.41 mcd/m2, Artif. bright. 2230 μcd/m2, Bortle class 6.